Experiences with a rat bio-assay in the diagnosis of the Zollinger-Ellison syndrome
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Experiences with a rat bio-assay in the diagnosis of the Zollinger-Ellison syndrome.
Reported here are the assay results, using the anaesthetized rat preparation of Lai (1964), of plasma from patients known or suspected to have peptide-secreting adenomata and these are compared with assays carried out on plasma from patients whose clinical history excluded such pathology. It is suggested that these demonstrate that this technique is of diagnostic value in this condition and tha...
متن کاملZollinger-Ellison Syndrome — Presentation, Diagnosis, Therapy
Zollinger-Ellison syndrome results from a pancreatic tumor in the non-beta islet cells, which stimulates the maximal activity of the gastric acid-secreting cells, resulting in gastrointestinal ulceration of the mucosa. Multiple endocrine neoplasia type 1 (MEN 1) is a familial autosomal dominant syndrome that includes Zollinger-Ellison syndrome as part of it; however, Zollinger-Ellison syndrome ...
متن کاملZollinger-Ellison syndrome
Since Zollinger and Ellison described in 1955 a pathological entity consisting of multiple recurrent peptic ulcerations, gastric hypersecretion, and islet cell tumours of the pancreas, several reports have been published dealing with the clinical and biological aspects of this new syndrome (Priest and Alexander, 1957;Summerskill, 1959; Gregory,Tracy, French, and Sircus, 1960; Grossman, Tracy, a...
متن کاملZollinger-Ellison Syndrome
Epidemiology The incidence of gastrinomas is 0.5-2/million population/year. [3] 20-30% of patients have ZES as part of MEN1, an autosomal dominant disorder. [4] Mean age of presentation is around 40, being younger in MEN1 patients than sporadic cases. Only about 3% present before age 20 and 7% after age 60. Gastrinomas are the most common functioning tumour of the pancreas. In addition to secre...
متن کامل[Zollinger-Ellison syndrome].
The preoperative localization of gastrinomas often fails despite all modern imaging methods. Therefore, after biochemical confirmation of the diagnosis and exclusion of diffuse metastases, a meticulous surgical exploration including intraoperative ultrasound (IOUS) and duodenal exploration after duodenotomy should be performed. The experienced surgeon will be able to identify more than 90% of t...
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ژورنال
عنوان ژورنال: Gut
سال: 1970
ISSN: 0017-5749
DOI: 10.1136/gut.11.5.409